Journal article
Targeting oncogenic drivers and the immune system in melanoma
GA McArthur, A Ribas
Journal of Clinical Oncology | AMER SOC CLINICAL ONCOLOGY | Published : 2013
Abstract
Melanoma is one of the most common cancers in Western countries but has defied the trend of reductions in age-adjusted mortality observed in most other cancers in recent years. Biologically, melanoma is characterized by a high propensity to metastasize at low tumor volumes necessitating the need for effective drug therapies to support efforts in prevention and early detection for reducing mortality. Efforts to study the clinical biology of melanoma have led to a new understanding of the disease, with genomic studies identifying several targetable oncogenes, in particular the protein kinases BRAF and KIT. Biologic studies have also identified a variety of immunologic targets, including the pr..
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Grants
Funding Acknowledgements
Supported by project Grant No. APP1002655 and a Research Fellowship from the National Health and Medical Research Council of Australia, by the Victorian Cancer Agency, and by the Cancer Council of Victoria Sir Edward Weary Dunlop Clinical Research Fellowship (G. A. M.); also supported by The Seaver Institute, the Louise Belley and Richard Schnarr Fund, the Wesley Coyle Memorial Fund, the Garcia-Corsini Family Fund, the Bila Alon Hacker Memorial Fund, the Fred L. Hartley Family Foundation, the Ruby Family Foundation, the Jonsson Cancer Center Foundation, the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at University of California, Los Angeles (UCLA), and the California Institute of Technology of California-UCLA Joint Center for Translational Medicine (A. R.).